Amantex ER 129 Tablet is a prescription medication used in the treatment of Parkinson’s disease and drug-induced movement disorders. It contains amantadine hydrochloride in an extended-release form, which ensures a gradual and sustained release of the drug over 24 hours. This helps maintain stable drug levels in the blood, reducing the frequency of symptoms throughout the day. Parkinson’s disease is a progressive neurological disorder that affects movement, balance, and coordination due to low dopamine levels in the brain. Amantex helps restore this balance, easing stiffness, tremors, and slowness of movement. It is also used to manage involuntary muscle movements caused by long-term use of antipsychotic medications.
Uses
- Parkinson’s disease
Benefits of Amantex ER 129
- Improves motor function: Reduces tremors, stiffness, and slowness in movement.
- Supports daily activities: Helps patients regain physical independence and comfort in performing tasks.
- Once-daily dosing: The extended-release formulation ensures consistent symptom control throughout the day.
- Treats drug-induced extrapyramidal symptoms: Useful for movement disorders caused by antipsychotic medications.
- Better patient compliance: Due to fewer daily doses and sustained efficacy.
How Amantex ER 129 Tablet works
Amantex ER 129 Tablet contains amantadine, a medicine that works by increasing dopamine levels in the brain. Dopamine is a neurotransmitter critical for controlling movement and coordination. In Parkinson’s disease, dopamine levels drop, leading to motor symptoms such as tremors, stiffness, and bradykinesia (slowness of movement). Amantex helps restore dopamine balance by:
- Enhancing dopamine release
- Inhibiting dopamine reuptake
- Weakly blocking NMDA (N-methyl-D-aspartate) receptors, which helps reduce involuntary movements
This combination of effects helps relieve motor symptoms, improve coordination, and support better quality of life for patients.
Side effects
- Dizziness
- Insomnia (difficulty sleeping)
- Nausea


